Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environmentArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis being Biomarker breath caused Compound condition conditions contagious disease transmission Effects examined immediate effect Infection infection risk infectious condition intensive care Observed offer Patient physiological point-of-care profiles protocol provided proximal reduce respiratory infections respiratory rate risk Safe SARS-CoV-2 specific effect subject Transmission Viral load VoC VOCs [DOI] 10.1038/s41598-022-22581-7 PMC 바로가기
Pulmonary Involvement in SARS-CoV-2 Infection Estimates Myocardial Injury RiskArticle Published on 2022-10-112022-11-15 Journal: Medicina [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome Admission age Alpha alveolar ambient biochemical biochemical marker Biomarker C reactive protein can be used cardiac injury chest scan Computerized tomography consecutive patients consolidation coronavirus correlated correlation COVID-19 COVID-19 complications COVID-19 patient COVID-19 risk factors CRP CT scan Diastolic blood pressure dysfunction elevated estimate Factor Factors fibrinogen group Hospitalization IL-6 Infection Inflammatory marker Injury interleukin-6 interlobular septal thickening interstitial Involvement lactate dehydrogenase LDH lesion lung Lung disease lung involvement material multisystemic myocardial injury myocardial injury. myocardial involvement Myoglobin Necrosis non-specific NT-proBNP objective Observational cohort study occurred parameters pathology Patient Patient care performed peripheral oxygen saturation Pneumonia pulmonary pulmonary involvement pulmonary lobe radiological Registered respiratory rate respiratory rates Result risk routine SARS-CoV-2 SARS-COV-2 infection Serum ferritin severity Sex significant difference Systolic blood pressure the disease the patient the study group TnI [DOI] 10.3390/medicina58101436 PMC 바로가기
Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severityArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] 바이오마커, 변종, [키워드] Amino acid amino acids analysed Analysis C-reactive protein Clinical diagnosis Clinical severity clinical suspicion Clinical tests collected COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Diagnosis diagnostic Disease progression driver dysregulation eliminating expand exploratory feature Health hospital hospitalised patient likelihood marker metabolomics Metadata Non-invasive offer outcomes Patient patients peripheral oxygen saturation Prognosis progressed receiver operating characteristics recent Research reservoir respiratory rate resulting reveal RT-PCR testing Saliva saliva sample serum severity shown the disease Treatment Vaccine variants [DOI] 10.1371/journal.pone.0274967 PMC 바로가기
Leukocyte glucose index as a novel biomarker for COVID-19 severityArticle Published on 2022-09-022022-11-15 Journal: Scientific Reports [Category] 바이오마커, [키워드] 95% confidence interval addition analyzed AUC biochemical Biomarker coronavirus disease COVID 19 COVID-19 COVID-19 patients COVID-19 severity evaluated female Glucose Host immune response independent risk factor involved leukocyte male metabolism Odds ratio outcome Patient patients patients with diabete potential risk predict respiratory parameter respiratory rate risk factor sensitivity severe COVID-19 severity specificity [DOI] 10.1038/s41598-022-18786-5 PMC 바로가기
Facilitating Safe Discharge Through Predicting Disease Progression in Moderate Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study to Develop and Validate a Clinical Prediction Model in Resource-Limited SettingsClinical Trial Published on 2022-08-242022-10-04 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] acute respiratory syndrome age biochemical Biomarker C-reactive protein clinical clinical parameter clinical utility clinician Cohort coronavirus coronavirus disease COVID-19 D-dimer death defined demonstrated develop evaluated expressed external validation Facilitating greater health system help hospital identify IL-6 India infections laboratory-confirmed LMIC low- and middle-income country management Model moderate Neutrophil-to-lymphocyte ratio NLR participant Patient patients with moderate prediction presenting Primary outcome procalcitonin prognostic prognostic model progression Prospective provided Rapid test receptor recruited resources respiratory rate SARS-CoV-2 setting Sex soluble Triggering Receptor SpO2 SpO2/FiO2 suPAR supplemental oxygen Symptom triage. utility Vaccines validation cohort [DOI] 10.1093/cid/ciac224 PMC 바로가기 [Article Type] Clinical Trial
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™SARS-COV-2 항바이러스 치료제 Paxlovid™의 적시 개발을 지원하는 Nirmatrelvir의 포괄적인 비임상 안전성 평가Article Published on 2022-08-012022-09-11 Journal: International journal of toxicology [Category] 치료제, [키워드] 3CL administration Antiviral Arrhythmias assessment blood pressure cardiovascular caused clinical development Clinical pathology coagulation time Comprehensive conducted COVID-19 COVID-19 patient COVID-19 patients death decrease decreases development dose Drug safety Effect Efficacy Endpoint enhancer enzyme functional heart rate high risk highest dose Hospitalization Increases increases in induce Infection locomotor male MPro nervous system Nirmatrelvir not affect pathology Paxlovid pharmacokinetic Potential produced profile protease RATs Replication respiratory rate Ritonavir Safety safety pharmacology SARS-CoV-2 SARS-CoV-2 virus Support Supporting target tested the SARS-CoV-2 virus toxicities Toxicity toxicology toxicology. transaminase transaminases Treatment treatment of COVID-19 were assessed [DOI] 10.1177/10915818221095489 PMC 바로가기 [Article Type] Article
Detecting early physiologic changes through cardiac implantable electronic device data among patients with COVID-19Research article Published on 2022-08-012022-10-05 Journal: Cardiovascular Digital Health Journal [Category] 치료기술, [키워드] acute COVID-19 acute infection Admissions age baseline cardiac Cardiac pacemaker change changed changes in Clinical data Clinical symptoms Cohort confidence interval control group COVID-19 COVID-19 test Electronic health records evaluated facilitate heart failure Implantable defibrillators Infection Intervention logistic regression models Mann-Whitney U objective Odds ratio Patient patients with COVID-19 Physiologic Physiologic monitoring positive predicted Prevent respiratory respiratory rate Result Sex Significant significantly Support worsening [DOI] 10.1016/j.cvdhj.2022.07.070 [Article Type] Research article
COVID-19 related acute necrotizing encephalopathy with extremely high interleukin-6 and RANBP2 mutation in a patient with recently immunized inactivated virus vaccine and no pulmonary involvement최근 면역 불활화 바이러스 백신을 접종하고 폐 침범이 없는 환자에서 매우 높은 인터루킨-6 및 RANBP2 돌연변이를 갖는 COVID-19 관련 급성 괴사성 뇌병증Case Reports Published on 2022-07-232022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Acute kidney injury Acute necrotizing encephalopathy ADE affecting alteration Analysis antibody blood pressure blood-brain barrier body temperature bpm Brain caused Celsius characteristic Chest Chest radiograph Clinical course Coma Computerized tomography consciousness COVID-19 COVID-19 vaccine cytokine cytokine signaling Cytokine storm Cytokines delta variant Encephalopathy examination Factor gene analysis heart rate hemorrhage hepatic failure heterozygous Hypothesis IL-6 immune response immunized inactivated Inactivated vaccine incidence of COVID-19 infiltration interleukin-6 lesion minute Missense mutation mitochondrial Mitochondrial function Mutation Necrosis oxygen oxygen saturation Pathogenesis Patient Potential treatment predictor preserved Previous studies Prognostic factor pulmonary disease pulmonary involvement pyelonephritis Ranbp2 RANBP2. reported respiratory respiratory rate role SARS-CoV-2 SARS-CoV2 infection Seizure Septic shock Sequencing Serum IL-6 Sinopharm Stupor Vaccine viral entry virus whole genome Whole genome sequencing [DOI] 10.1186/s12879-022-07610-0 PMC 바로가기 [Article Type] Case Reports
Randomized controlled phase 2 trial of hydroxychloroquine in childhood interstitial lung diseaseClinical Trial Published on 2022-07-232022-10-05 Journal: Orphanet Journal of Rare Diseases [Category] COVID19(2023년), SARS, 임상, [키워드] absence adverse event age all subject approval ARMS calculated chILD. childhood children Controlled trial double-blind effect size Endpoint evaluated four subject groups HCQ Health Hydroxychloroquine identify Interstitial lung disease Interstitial lung diseases lack lung Lung function multicentre Munich not differ not different offered outcome Oxygenation participated phase 2 trial Placebo placebo-controlled primary endpoint Pulmonary function Quality of life Randomized randomized-controlled trial Registered Registration respiratory rate Respiratory Support secondary study population subject Treatment treatment effects treatment period Trial university were given Withdrawal [DOI] 10.1186/s13023-022-02399-2 PMC 바로가기 [Article Type] Clinical Trial
A randomised pilot trial of virtual reality-based relaxation for enhancement of perioperative well-being, mood and quality of life Research Published on 2022-07-142022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] 95% CI adherence Affect assigned cancer diagnosis cancer patient Cancer patients changes in Clinical effect Clinical outcome Colorectal cancer control group demonstrated distress Effect feasibility group in both group Intervention intervention group liver no difference Observed participant Patient pilot study Quality of life randomised receiving recruited reduced reported Research resources respiratory rate significantly standard treatment subsequent three groups Treatment Trial vital sign [DOI] 10.1038/s41598-022-16270-8 [Article Type] Research